Working for more than twenty years in the development of synchrotron instrumentation for structural biology. I have built and operated beam lines at the SRS Daresbury – firstly UV-vis instruments for spectroscopy and photo-fragmentation experiment and then for their first tunable anomalous dispersion beamline. Moving to the EMBL Grenoble I constructed beamlines at the European synchrotron (ESRF) including the first dedicated undulator beam line, in this period I established an firm interest in data collection methods, the issues associated with X-ray radiation damage and the automation of MX experiments. In July 2000 I moved to the ESRF in order to establish a structural biology group, this group had the functions of developing and operating the beamline instrumentation and also the creation of an in-house structural biology research program. Both endeavors succeed establishing a vibrant culture of research and team work in the laboratory, this work also lead to us creating a partnership for structural biology (http://psb-grenoble.eu) linking the International institutes in Grenoble (ILL, ESRF and EMBL) with the French research community in the city. In October 2013 I joined BNL where we will establish world-leading facilities for the use of synchrotron radiation at the NSLS-II.
RESEARCH INTERESTS: Structural Biology, Synchrotron Radiation, Macromolecular Crystallography, Radiation Damage in Biological systems, DNA repair processes, membrane transport, imaging techniques for Biology.