Lisa Miller Biophysical Chemist Lisa Miller is the Associate Division Director for Spectroscopy, Imaging, and Structural Biology in the Photon Sciences Directorate at Brookhaven National Laboratory. She is also the spokesperson for Beamlines U2B and U10B at the NSLS. Beamlines U2B and U10B specialize in mid-infrared microspectroscopy and full-field imaging of materials such as biological cells and tissues, plants, microbes, polymers, soils, and minerals. Lisa Miller's research focuses on the study of the chemical makeup of tissue in disease using high-resolution infrared and x-ray imaging. Her work has two primary research areas: (1) examination of the chemical composition of bone tissue in diseases such as osteoarthritis and osteoporosis, and (2) correlation of metal ion content and protein structure in neurological tissue in protein-folding diseases such as Alzheimer's disease and Lou Gehrig's disease. Professional Activities

Phone: 344-2091 Fax: 631-344-3238 Email: lmiller@bnl.gov

Education

• Ph.D. 1995: Biophysics, Albert Einstein College of Medicine
• M.S. 1992: Chemistry, Georgetown University
• B.S. 1989: Chemistry, John Carroll University

Projects

• Investigating Bone Chemistry using Reflection-Based Infrared Imaging
• Time-Dependent Metal Accumulation in the Brain of a Mouse Model of Alzheimer’s Disease
• Co-Localization of Beta Amyloid Deposits and Metal Accumulation in Human Alzheimer's Disease
• In Situ Prion Protein Structural Changes in Scrapie
• Pinpointing the Chemistry Behind Stiffening Bones
• Chemical Makeup of Microdamaged Bone
• Affects of Hormone and Bisphosphonate Treatment in Osteoporosis
• Catalysis of Biodegradable Polymers with Immobilized Enzymes
• Matrix Metalloproteinase Degradation of Extracellular Matrix in Tumor Growth
• Compositional Tissue Changes in Inflammatory Cardiomyopathy
• High Throughput Biophysical Analyses of Protein Structure
• Development of an Epifluorescence Module for Infrared and X-Ray Imaging
• A New Sample Substrate for Correlating Infrared and X-Ray Images

Key Publications

• R Pietri, S Zerbs, D Corgliano, M Allaire, F Collart, L Miller, Biophysical and Structural Characterization of a Sequence-diverse Set of Solute-binding Proteins for Aromatic Compounds, J. Biol. Chem., 287(28), 23748-23756 (2012).
• M Bourassa, L Miller, Metal Imaging in Neurodegenerative Diseases, Metallomics, 4(8), 721-738 (2012).
• A Acerbo, G Carr, S Judex, L Miller, Imaging the Material Properties of Bone Specimens Using Reflection-Based Infrared Microspectroscopy, Anal. Chem., 84(8), 3607-3613 (2012).
• A Leskovjan, A Kretlow, A Lanzirotti, R Barrea, S Vogt, L Miller, Increased Brain Iron Coincides with Early Plaque Formation in a Mouse Model of Alzheimer's Disease, NeuroImage, 55, 32-38 (2011).
• L Miller, P Dumas, From Structure to Cellular Mechanism with Infrared, Curr. Opin. Struct. Biol., 20(5), 649-656 (2010).

All Publications

Links

• Research Group Homepage
• Infrared Homepage
• Beamline U10B Homepage
• Beamline U2B Homepage
• InSynC Homepage