Lisa Miller

Biophysical Chemist

Lisa Miller is the Associate Division Director for Spectroscopy and Imaging in the Photon Sciences Directorate at Brookhaven National Laboratory. She is also the spokesperson for Beamlines U2B and U10B at the NSLS. Beamlines U2B and U10B specialize in mid-infrared microspectroscopy and full-field imaging of materials such as biological cells and tissues, plants, microbes, polymers, soils, and minerals.

Lisa Miller's research focuses on the study of the chemical makeup of cells and tissues using synchrotron-based infrared and x-ray imaging. Her work has three primary research areas: (1) understanding how the nanostructure and chemical composition of bone affect its mechanical properties in osteoarthritis and osteoporosis, (2) elucidating the role of metal ions in protein misfolding and neurodegeneration in Alzheimer's disease and amyotrophic lateral sclerosis, and (3) optimizing nutrient availability in the rhizosphere of plants for improved biomass production.

Professional Activities

Phone: 344-2091


  • Ph.D. 1995: Biophysics, Albert Einstein College of Medicine
  • M.S. 1992: Chemistry, Georgetown University
  • B.S. 1989: Chemistry, John Carroll University


Key Publications

  • E Stavitski, R Smith, M Bourassa, A Acerbo, G Carr, L Miller, Dynamic Full-Field Infrared Imaging with Multiple Synchrotron Beams, Anal. Chem., 85(7), 3599-3605 (2013).
  • R Pietri, S Zerbs, D Corgliano, M Allaire, F Collart, L Miller, Biophysical and Structural Characterization of a Sequence-diverse Set of Solute-binding Proteins for Aromatic Compounds, J. Biol. Chem., 287(28), 23748-23756 (2012).
  • A Acerbo, G Carr, S Judex, L Miller, Imaging the Material Properties of Bone Specimens Using Reflection-Based Infrared Microspectroscopy, Anal. Chem., 84(8), 3607-3613 (2012).
  • A Leskovjan, A Kretlow, A Lanzirotti, R Barrea, S Vogt, L Miller, Increased Brain Iron Coincides with Early Plaque Formation in a Mouse Model of Alzheimer's Disease, NeuroImage, 55, 32-38 (2011).
  • L Miller, P Dumas, From Structure to Cellular Mechanism with Infrared, Curr. Opin. Struct. Biol., 20(5), 649-656 (2010).

All Publications